While the spoilers for Murders at Karlov Manor continue to trickle in, there is a clearly defining characteristic that many of the cards share:
Clue
Clue
{2}, Sacrifice this token: Draw a card.
s. There are equipment clues, plenty of spells that make clue tokens and even new lands that all can generate a clue. Support already exists both for and against a
Clue
Clue
{2}, Sacrifice this token: Draw a card.
heavy meta, and many of these cards already see a fair amount of play in Commander. First up, some monster green cards that beat clues to a pulp.
Much Hype, Some Substance

Just a few years ago
Viridian Revel
Viridian Revel
Whenever an artifact is put into an opponent's graveyard from the battlefield, you may draw a card.
spiked wildly in price as set after set kept introducing new token artifacts to sacrifice like
Food
Food
{2}, {T}, Sacrifice this token: You gain 3 life.
,
Blood
Blood
{1}, {T}, Discard a card, Sacrifice this token: Draw a card.
,
Treasure
Treasure
Trample
and of course
Clue
Clue
{2}, Sacrifice this token: Draw a card.
. The Lost Caverns of Ixalan has also introduced
Map
Map
{1}, {T}, Sacrifice this artifact: Target creature you control explores. Activate only as a sorcery. (Reveal the top card of your library. Put that card into your hand if it's a land. Otherwise, put a +1/+1 counter on that creature, then put the card back or put it into your graveyard.)
tokens as well.
Of course, Revel works with any artifacts going to the graveyard, not just tokens. While the price and the hype on this card has cooled a bit, it’s still a very playable card, and in light of another set with a heavy artifact sacrifice theme, it can only perform even better. If you have slotted out Viridian Revel for something else, consider giving it another try. You may be pleasantly surprised but how solid it is.
Smothering Tithe
Smothering Tithe
Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")
is four mana in white, the worst ramp color, and Revel is only three mana in green, the color with the best mana generation in the game.
An Old School Green Option

First, this stops non-creature artifacts cold turning off all their abilities. Next, it turns them into creatures. Finally, it has a unique effect that persists until end of turn, so even if it’s removed, it effectively is not for that turn, at least.
Titania’s Song
Titania’s Song
Each noncreature artifact loses all abilities and becomes an artifact creature with power and toughness each equal to its mana value. If this enchantment leaves the battlefield, this effect continues until end of turn.
turns artifact tokens into 0/0 creatures with no abilities. This card effectively beats
Smothering Tithe
Smothering Tithe
Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")
and
Dockside Extortionist
Dockside Extortionist
When this creature enters, create X Treasure tokens, where X is the number of artifacts and enchantments your opponents control. (Treasure tokens are artifacts with "{T}, Sacrifice this token: Add one mana of any color.")
as just a couple of powerful examples. Four mana is not a lot in green, so this is an easy spell to cast. Considering Clues, they just go to the graveyard.
Now, Titania’s Song could be an advantage too. Maybe you want something to trigger Investigate, making a bunch of clues, but you want them to go to the graveyard for
Marionette Master
Marionette Master
Fabricate 3 (When this creature enters, put three +1/+1 counters on it or create three 1/1 colorless Servo artifact creature tokens.)
Whenever an artifact you control is put into a graveyard from the battlefield, target opponent loses life equal to this creature's power.
or
Disciple of the Vault
Disciple of the Vault
Whenever an artifact is put into a graveyard from the battlefield, you may have target opponent lose 1 life.
. The Song is useful in a variety of situations. Considering that you can find this for just a dollar, it’s a great deal!
Landfall

Green has plenty of ways to fight clues including
Collector Ouphe
Collector Ouphe
Activated abilities of artifacts can't be activated.
, but it also has ways to use them.
Tireless Tracker
Tireless Tracker
Landfall — Whenever a land you control enters, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this token: Draw a card.")
Whenever you sacrifice a Clue, put a +1/+1 counter on this creature.
gives you a very easy way for green to generate an excessive number of clues very quickly. As a side-effect to sacrificing clues, your Tracker is going to grow to epic proportions. Note that you don’t have to activate the clues, or pay mana. Merely sacrificing the clues will permanently boost the Tracker. What better way, in green, than the innocuous
Glimmer Bairn
Glimmer Bairn
Sacrifice a token: This creature gets +2/+2 until end of turn.
? Having two massive creatures for very little mana is what green loves to do and clues can easily help you get there.
Big Mana Synergy

Just imagine if instead of Investigate making a clue, you made a
Mox Emerald
Mox Emerald
{T}: Add {G}.
! Well,
Jaheira, Friend of the Forest
Jaheira, Friend of the Forest
Tokens you control have "{T}: Add {G}."
Choose a Background (You can have a Background as a second commander.)
allows you to do just that. Not only will she turn all your clues into mana rocks, she also is great as a potential Commander using the Background mechanic. Both
Agent of the Iron Throne
Agent of the Iron Throne
Commander creatures you own have "Whenever an artifact or creature you control is put into a graveyard from the battlefield, each opponent loses 1 life."
and
Street Urchin
Street Urchin
Commander creatures you own have "{1}, Sacrifice another creature or an artifact: This creature deals 1 damage to any target."
give you a way to turn your clues into not only mana, but also a win condition. Green is no stranger to token doubling with mana effects like
Parallel Lives
Parallel Lives
If an effect would create one or more tokens under your control, it creates twice that many of those tokens instead.
or
Doubling Season
Doubling Season
If an effect would create one or more tokens under your control, it creates twice that many of those tokens instead.
If an effect would put one or more counters on a permanent you control, it puts twice that many of those counters on that permanent instead.
at the ready.
Potential Synergy in Black

First, we have not seen much out of black for Murders at Karlov Manor. Second, the color is historically weak to both artifacts and enchantments. Even so
Braids, Arisen Nightmare
Braids, Arisen Nightmare
At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent of their choice that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.
lets you turn extra clue tokens into edict effects than can also deal damage and draw you cards. Clearly there will be excess clue tokens aplenty, so Braids turns your slow draw power into faster draw power that also can set your opponents back. It’s a bit speculative, but the set definitely will boost Braids power a little.
Black does, however, get to include
Havengul Laboratory
Havengul Laboratory
{T}: Add {C}.
{4}, {T}: Investigate. (Create a colorless Clue artifact token with "{2}, Sacrifice this artifact: Draw a card.")
At the beginning of your end step, if you sacrificed three or more Clues this turn, transform Havengul Laboratory.
as it has black color identity. A relatively free reanimation effect that takes up no deck space makes this card an auto include in every black deck with a clue theme.
Red Always has Interesting Answers

Is your opponent trying to maintain a critical mass of clues to go off? Meet
Sardian Avenger
Sardian Avenger
First strike, trample
Whenever this creature attacks, it gets +X/+0 until end of turn, where X is the number of artifacts your opponents control.
Whenever an artifact an opponent controls is put into a graveyard from the battlefield, this creature deals 1 damage to that player.
who can attack into pretty much anything for value. Keep this idea in mind because it’s all about diplomacy.
You see, clues tend to stick around a relatively long time, they offer a slow advantage, but you do not have to attack the player massing up clues to get the bonus. Therefore, they are helping you take down the other two players. Meanwhile, when they crack their clues, they are still taking damage for it. For only two mana, the Avenger has the potential to deal gobs of damage in multiplayer. Considering you’re in red, you have easy access to double-strike and double damage effects to one shot players. Let that player make
Treasure
Treasure
Trample
off their
Smothering Tithe
Smothering Tithe
Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")
and the Avenger can punish them pretty quickly, especially if the entire table joins in. Normally it’s a bad idea to just give someone a pile of treasure but in this case, it may be their undoing.
Doctor Who is all About Clues

There are a lot of potential combinations of Commanders from the MTG Doctor Who set. While Jenny Flynt and
Madame Vastra
Madame Vastra
Partner with Jenny Flint (When this creature enters, target player may put Jenny Flint into their hand from their library, then shuffle.)
Madame Vastra must be blocked if able.
Whenever a creature dealt damage by Madame Vastra this turn dies, create a Clue token and a Food token.
could be decent Commander for this style of deck, I think they would be better off as a tutoring pair in the 98. Meanwhile,
Nyssa of Traken
Nyssa of Traken
You have no maximum hand size.
Sonic Booster — Whenever Nyssa of Traken attacks, sacrifice any number of artifacts. When you sacrifice one or more artifacts this way, tap up to that many target creatures and draw that many cards.
Doctor's companion (You can have two commanders if the other is the Doctor.)
is the real Commander of the deck with
The Fugitive Doctor
The Fugitive Doctor
When The Fugitive Doctor enters, investigate.
Whenever The Fugitive Doctor attacks, you may sacrifice a Clue. When you do, target instant or sorcery card in your graveyard gains flashback {2}{R}{G} until end of turn. (You may cast that card from your graveyard for its flashback cost. Then exile it.)
as the backup plan. You should be able to easily make three to five clues before Nyssa takes her first swing and refills your hand. Even if you draw too much, she removes your hand size limit!
If things don’t work out, your Doctor can come in, generate a clue and then start using Flashback to replay all your spells. Once you generate even more clues, Nyssa will get back to work drawing a gazillion cards. Both green and blue have tons of excellent support for this type of game plan. Blue even ramps hard with
Five Hundred Year Diary
Five Hundred Year Diary
Five Hundred Year Diary enters tapped.
{T}: Add {U} for each Clue you control.
{2}, Sacrifice Five Hundred Year Diary: Draw a card.
. Red will have excellent spells that you want to flash back and can also make a lot of treasure which will have synergy with the rest of the deck and other auto includes.
Then Again, so is Stranger Things

Mardu is allowed to get in on the
Clue
Clue
{2}, Sacrifice this token: Draw a card.
based fun with these two Commanders. This pairing is very forward looking because both black and red are relatively light on overall
Clue
Clue
{2}, Sacrifice this token: Draw a card.
synergy. White certainly has some nice effects that can appreciate these Commanders. There are existing artifact and sacrifice based strategies utilizing
Marionette Master
Marionette Master
Fabricate 3 (When this creature enters, put three +1/+1 counters on it or create three 1/1 colorless Servo artifact creature tokens.)
Whenever an artifact you control is put into a graveyard from the battlefield, target opponent loses life equal to this creature's power.
as mentioned briefly above but you can easily go a different way. Note how
Wernog, Rider’s Chaplain
Wernog, Rider’s Chaplain
When Wernog, Rider's Chaplain enters or leaves the battlefield, each opponent may investigate. Each opponent who doesn't loses 1 life. You investigate X times, where X is one plus the number of opponents who investigated this way.
Partner—Friends forever (You can have two commanders if both have this ability.)
gives your opponents clues which boosts up
Sardian Avenger
Sardian Avenger
First strike, trample
Whenever this creature attacks, it gets +X/+0 until end of turn, where X is the number of artifacts your opponents control.
Whenever an artifact an opponent controls is put into a graveyard from the battlefield, this creature deals 1 damage to that player.
. With a bit of help from Murders at Karlov Manor, this could be the start of some very interesting looking decks.
Speaking of White

It appears that
Thorough Investigation
Thorough Investigation
Whenever you attack, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this token: Draw a card.")
Whenever you sacrifice a Clue, venture into the dungeon. (Enter the first room or advance to the next room.)
has already spiked in price and for good reason as it’s the best investigate card in white with the highest
Clue
Clue
{2}, Sacrifice this token: Draw a card.
synergy.
The dungeon mechanic, overall, is relatively slow but it does provide advantage. If you can turbo your way through an entire dungeon all at once, at instant speed, however, you can have a surprising impact at any stage of a game. While
Search the Premises
Search the Premises
Whenever a creature attacks you or a planeswalker you control, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this token: Draw a card.")
deserves a mention, it relies too much on your opponents to gain value. Thorough Investigation gives you explosive potential as long as you have a sacrifice outlet for your clues and is a card with strong potential. Once we see more of Murders at Karlov Manor you may end up wanting it.
Blue has too much…

First, let’s talk about some multicolored cards that include blue.
Lonis, Cryptozoologist
Lonis, Cryptozoologist
Whenever another nontoken creature you control enters, investigate.
{T}, Sacrifice X Clues: Target opponent reveals the top X cards of their library. You may put a nonland permanent card with mana value X or less from among them onto the battlefield under your control. That player puts the rest on the bottom of their library in a random order.
is likely an auto-include in any clue heavy simic deck and a combo commander.
Time Sieve
Time Sieve
{T}, Sacrifice five artifacts: Take an extra turn after this one.
loves to eat extra clues and it’s quite possible to make enough each turn to go infinite. Surely Eloise, Nephalia Sleuth,
Inquisitor Eisenhorn
Inquisitor Eisenhorn
You may reveal the first card you draw each turn as you draw it. Whenever you reveal an instant or sorcery card this way, create Cherubael, a legendary 4/4 black Demon creature token with flying.
Whenever Inquisitor Eisenhorn deals combat damage to a player, investigate that many times. (Create a Clue token. It's an artifact with "{2}, Sacrifice this token: Draw a card.")
, and
Inquisitor Greyfax
Inquisitor Greyfax
Vigilance
Unquestionable Wisdom — Other creatures you control get +1/+0 and have vigilance.
Hunt for Heresy — {1}, {T}: Tap target creature an opponent controls. Investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this token: Draw a card.")
will all see play. But what are the absolute standout mono-blue cards?
It’s a toss up between Trail of Evidence and
Ethereal Investigator
Ethereal Investigator
Flying
When this creature enters, investigate X times, where X is the number of opponents you have. (To investigate, create a Clue token. It's an artifact with "{2}, Sacrifice this token: Draw a card.")
Whenever you draw your second card each turn, create a 1/1 white Spirit creature token with flying.
. The Investigator has tremendous upside when it’s generating three clues every time it enters the battlefield. This card wants to be bounced, blinked, flickered and reanimated. On top of making a pile of clues, it also is quite easy to generate some additional 1/1 spirit tokens for even more value. Meanwhile, Trail of Evidence just generates a clue for every instant or sorcery you cast, so if you’re a spell heavy deck, it will do a large amount of work. Where there is smoke, there is fire, and many decks will simply play both.
There can be only one best Artifact

Let’s face it, generating a single
Clue
Clue
{2}, Sacrifice this token: Draw a card.
is not that exciting. But turning that one token into three is absolutely busted and part of an ever growing list of infinite combos. Many of those combos are easily enabled by Academy Manufactor. While there are plenty of clue based artifacts, Manufactor is heads and shoulders above the rest. Any token based deck already runs this card but Murders at Karlov Manor could boost the play rate considerably.
Clues and Investigation
There’s not much to go on right now in regards to just how Murders at Karlov Manor will impact Magic’s various formats. Even with only these two mechanics in play, there are a lot of cards ready to see more play. Based on pure speculation, there should be all manner of card archetypes that will soon interact with
Clue
Clue
{2}, Sacrifice this token: Draw a card.
tokens. Don’t be surprised if there are board wipes, bounces, and scaling bonuses that all key off of clues. Whether you are building your own stack of tokens or stymieing your opponents there are always good options that already exist that can become excellent options after a new set.